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  • Received: Jul. 31, 2018

    Accepted: Oct. 24, 2018

    Posted: Mar. 1, 2019

    Published Online: Nov. 14, 2019

    The Author Email: SUN Ping (pingsun@bnu.edu.cn)

    DOI: 10.1007/s12200-019-0861-1

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    Jiayu LI, Yijun XIE, Ping SUN. Edge detection on terahertz pulse imaging of dehydrated cutaneous malignant melanoma embedded in paraffin[J]. Frontiers of Optoelectronics, 2019, 12(3): 317

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Frontiers of Optoelectronics, Vol. 12, Issue 3, 317 (2019)

Edge detection on terahertz pulse imaging of dehydrated cutaneous malignant melanoma embedded in paraffin

Jiayu LI, Yijun XIE, and Ping SUN*

Author Affiliations

  • Beijing Key Laboratory of Applied Optics, Department of Physics, Beijing Normal University, Beijing 100875, China

Abstract

Terahertz pulse imaging of cutaneous malignant melanoma dehydrated by ethanol and embedded in paraffin was carried out across a frequency range of 0.2–1.4 THz. First, the tissue images based on the time-domain electric-field amplitude information were acquired. Then the areas of normal and cancerous tissues were determined using multi-scale, multi-azimuth and multi-structural element mathematical morphology. The physical meaning of the image was analyzed by calculation of the refractive index and absorption coefficient of cutaneous malignant melanoma in different areas. The refractive index of both normal and cancerous tissues showed anomalous dispersion. The refractive index of cancerous tissues tended to vary between 0.2 and 0.7 THz, while that of normal and fat tissues remain almost unchanged. The absorption of cancerous tissues was higher, with a maximum at 0.37 THz. We concluded that both the refractive index and absorption coefficient differ considerably between normal and cancerous tissues, and the areas of normal and abnormal tissues can be identified using THz pulse imaging combined with mathematical morphology. The method for edge detection of terahertz pulse imaging of cutaneous malignant melanoma provides a reference for the safe surgical removal of malignant tumors.

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