Chinese Optics Letters, Vol. 16, Issue 8, 081701 (2018)
3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging
Zhongwen Cheng1,2, Haigang Ma2, Zhiyang Wang2, and Sihua Yang1,2,*
- 1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
- 2College of Biophotonics, South China Normal University, Guangzhou 510631, China
Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.