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  • Received: May. 16, 2018

    Accepted: Jun. 6, 2018

    Posted: Jan. 17, 2019

    Published Online: Aug. 2, 2018

    The Author Email: Sihua Yang (yangsh@scnu.edu.cn)

    DOI: 10.3788/COL201816.081701

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    Zhongwen Cheng, Haigang Ma, Zhiyang Wang, Sihua Yang. 3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging[J]. Chinese Optics Letters, 2018, 16(8): 081701

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Chinese Optics Letters, Vol. 16, Issue 8, 081701 (2018)

3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging

Zhongwen Cheng1,2, Haigang Ma2, Zhiyang Wang2, and Sihua Yang1,2,*

Author Affiliations

  • 1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
  • 2College of Biophotonics, South China Normal University, Guangzhou 510631, China

Abstract

Photoacoustic (PA) microscopy comes with high potential for human skin imaging, since it allows noninvasively high-resolution imaging of the natural hemoglobin at depths of several millimeters. Here, we developed a PA microscopy to achieve high-resolution, high-contrast, and large field of view imaging of skin. A three-dimensional (3D) depth-coding technology was used to encode the depth information in PA images, which is very intuitive for identifying the depth of blood vessels in a two-dimensional image, and the vascular structure can be analyzed at different depths. Imaging results demonstrate that the 3D depth-coded PA microscopy should be translated from the bench to the bedside.