Chinese Optics Letters, Vol. 16, Issue 3, 031702 (2018)
Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment
Mingjun Xu1, Peng Lei2, Jianqin Feng3, Fangfang Liu1, Sihua Yang2,*, and Pengfei Zhang1,**
- 1Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China
- 2MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
- 3Department of Cardiology, The Juye Hospital of Traditional Chinese Medicine, Heze 274900, China
Photoacoustic imaging (PAI) has been used to characterize the spatial and quantitative features of lipid-rich atherosclerotic plaques with high sensitivity and specificity. In this Letter, we first validate that the ultra-low temperature and formaldehyde treatment have no effect on photoacoustic characteristics of the artery samples. Comparative experiments between the PAI and histological results demonstrate that the ultra-low temperature or formaldehyde treatment has few effects on the PAI of the lipid-rich atherosclerotic plaques; the lipid relative concentration and the lipid percentage by PAI hold high correlation with histology.