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  • Received: Mar. 26, 2004

    Accepted: --

    Posted: Jun. 6, 2006

    Published Online: Jun. 6, 2006

    The Author Email: Kexin Xu (kexin@tju.edu.cn)

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    Wenliang Chen, Rong Liu, Houxin Cui, Kexin Xu, Lina Lv. Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration[J]. Chinese Optics Letters, 2004, 2(7): 07411

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Chinese Optics Letters, Vol. 2, Issue 7, 07411 (2004)

Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration

Wenliang Chen, Rong Liu, Houxin Cui, Kexin Xu*, and Lina Lv

Author Affiliations

  • State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072

Abstract

In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed, and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/l, respectively.

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