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  • Received: Dec. 1, 2018

    Accepted: Mar. 14, 2019

    Posted: June. 12, 2019

    Published Online: June. 12, 2019

    The Author Email: Xiaoxia Yang (yangxx@nanoctr.cn), Qing Dai (daiq@nanoctr.cn)

    DOI: 10.3788/COL201917.062401

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    Chenchen Wu, Ning Liu, Hai Hu, Xiangdong Guo, Baoxin Liao, Jiaming Liu, Liming Wang, Chunying Chen, Xiaoxia Yang, Qing Dai. Detecting molecular vibrational modes of side chains and endpoints in nanoscale proteins with graphene plasmon[J]. Chinese Optics Letters, 2019, 17(6):062401-1

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Chinese Optics Letters, Vol. 17, Issue 6, 062401-1 (2019)

Detecting molecular vibrational modes of side chains and endpoints in nanoscale proteins with graphene plasmon

Chenchen Wu1,2, Ning Liu1,2, Hai Hu1,2, Xiangdong Guo1,2, Baoxin Liao1,2, Jiaming Liu2,3, Liming Wang4, Chunying Chen2,3, Xiaoxia Yang1,2,**, and Qing Dai1,2,*

Author Affiliations

  • 1Division of Nanophotonics, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
  • 2Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
  • 3CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
  • 4Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

Abstract

Monitoring the chemical and structural changes in protein side chains and endpoints by infrared (IR) spectroscopy is important for studying the chemical reaction and physical adsorption process of proteins. However, the detection of side chains and endpoints in nanoscale proteins is still challenging due to its weak IR response. Here, by designing a double layered graphene plasmon sensor on MgF2/Si substrate in the IR fingerprint region, we detect the vibrational modes in side chains and endpoints (1397 cm−1 and 1458 cm−1) of monolayer protein. The sensor could be applied on biochemistry to investigate the physical and chemical reaction of biomolecules.