Journal of Infrared and Millimeter Waves, Vol. 38, Issue 3, 389 (2019)
The optical properties and dynamical property of biological sample determined simultaneously by diffuse correlation spectroscopy
De-Tian WANG*, Heng-Xing LYU, Peng GAO, Sheng-Fu LI, Li-Guo ZHU, Qi-Xian PENG, Ze-Ren LI, and Jian-Heng ZHAO
- [in Chinese]
Near-infrared spectroscopy is a promising method to monitor the characteristics of biological samples noninvasively in biomedical field, food safety field, agricultural field, etc. But most studies focus on the measurement of optical properties of biological samples in these fields. Utilizing the latest developed diffuse correlation spectroscopy device and 30% intralipid as the phantom of biological sample, we demonstrated how to obtain both of the optical properties and dynamical property of 30% intralipid. The absorption coefficient and reduced scattering coefficient of 30% intralipid are 0.037 cm-1 and 303 cm-1 respectively. The Brownian diffusion coefficient of the diluted 30%intralipid (0.85%, volume/volume) is 8.40×10-9 cm2/s and the radius of intralipid particle is about 253 nm deduced by Stokes-Einstein relation. The stability of the diluted 30% intralipid was also studied. The scattering coefficient increases by 106% and the Brownian diffusion coefficient decreases by 63% for seven days. This study suggests that diffuse correlation spectroscopy can not only measure the optical properties but also measure the dynamical property of biological sample, which may be a powerful tool in biomedical field, food safety field , agricultural field, etc.
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