Main > Photonics Research >  Volume 8 >  Issue 7 >  Page 07001253 > Article
  • Abstract
  • Abstract
  • Figures (8)
  • Tables (0)
  • Equations (3)
  • References (37)
  • Suppl. Mat.
  • Get PDF
  • View Full Text
  • Paper Information
  • Received: Apr. 24, 2020

    Accepted: Jun. 4, 2020

    Posted: Jun. 4, 2020

    Published Online: Jun. 30, 2020

    The Author Email: Renjie Zhou (rjzhou@cuhk.edu.hk)

    DOI: 10.1364/PRJ.396135

  • Get Citation
  • Copy Citation Text

    Mengxuan Niu, Gang Luo, Xin Shu, Fuyang Qu, Shuang Zhou, Yi-Ping Ho, Ni Zhao, Renjie Zhou. Portable quantitative phase microscope for material metrology and biological imaging[J]. Photonics Research, 2020, 8(7): 07001253

    Download Citation

  • Category
  • Imaging Systems, Microscopy, and Displays
  • Share
Photonics Research, Vol. 8, Issue 7, 07001253 (2020)

Portable quantitative phase microscope for material metrology and biological imaging

Mengxuan Niu1, Gang Luo2, Xin Shu1, Fuyang Qu1, Shuang Zhou2, Yi-Ping Ho1,3, Ni Zhao2, and Renjie Zhou1,4,*

Author Affiliations

  • 1Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
  • 2Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
  • 3Centre for Novel Biomaterials, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
  • 4Shun Hing Institute of Advanced Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China

Abstract

Quantitative phase microscopy (QPM) has emerged as an important tool for material metrology and biological imaging. For broader adoption in those applications, we have proposed and demonstrated a new portable off-axis QPM method, which works in both transmission and reflection modes to meet different sample measurement requirements. The temporal and spatial sensitivities of our system, as quantified by optical path-length difference values, are 0.65 nm and 1.04 nm, respectively. To demonstrate its applicability for a wide range of applications, we deployed our system for profiling transistor gold electrode samples, observing red blood cell membrane fluctuations, imaging living cells flowing in a microfluidic chip, etc. Our portable QPM system has a low-cost design and involves a simple and robust phase-retrieval algorithm that we envision will allow for broader deployment at different environmental settings, including in resource-limited sites and integration with other metrology or imaging modalities.

Please Enter Your Email: