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  • Manuscript Accepted: Oct. 9, 2020

    Online Published: Oct. 10, 2020

Chinese Optics Letters, 2020, Vol. 18, Issue 12, pp.

The Feasibility Study for Bone Health Assessment Based on Photoacoustic Imaging Method  [Early Posting]

Feng Ting, Zhu Yunhao, Xie Yejing, Ta Dean, Yuan Jie, Cheng Qian

Author Affiliations

  • Nanjing University of Science and Technology
  • Nanjing University
  • Nanjing University of Science and Technology
  • Fudan University
  • School of Electronic Science and Engineering
  • Tongji University

Abstract

This study investigated the feasibility of photoacoustic (PA) imaging of bone and characterization of bone features. By conducting the experiments on the bovine femoral heads ex vivo, the light and ultrasonic penetration in bones was studied, together with the depth of PA imaging and measurement in bones. Then, the possibility of PA imaging of bones by raster scanning of the focusing transducer was studied. The micro-CT images of the bovine ribs with and without ethylenediaminetetraacetic acid (EDTA) treatment indicated that the PA images could present the changes of bone microstructure result from the EDTA treatment. By using PA spectral analysis (PASA), the bone samples with and without the treatment of EDTA solution can be distinguished, and the microstructures can be characterized. This study was based on the bovine bone whose size comparable to human bones, suggesting that PA technology can be used as a novel bone diagnostic technique.

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